Kyoto University Graduate School of Medicine, Kyoto University Big Data Medical Science, Okuno Laboratory

SEUNGEON LEE

PORTFOLIO

Researching AI-driven drug discovery for medium-sized peptides, focusing on peptide language models and property prediction.

ABOUT

Seungeon Lee

LEE SEUNGEON  /  李 昇彦
Graduate School of Medicine, Kyoto University
Big Data Medical Science, Okuno Laboratory

AI Drug Discovery / Cheminformatics / Medium-sized Peptides / Machine Learning

I am a Master's student at the Graduate School of Medicine, Kyoto University, working in the Okuno Laboratory on AI-driven drug discovery. My current research focuses on transformer-based language models for medium-sized peptide property prediction, bridging the gap between small-molecule and protein informatics.

BIOGRAPHY

2025.04 – Present

Graduate Student (M.S.)

Kyoto University, Graduate School of Medicine, Division of Human Health Sciences (Okuno Laboratory)

2025.03

Undergraduate (B.Sc.)

Kwansei Gakuin University, School of Science and Technology, Department of Bioscience (Miura Laboratory)

BIBLIOGRAPHY

ARTICLES

  1. HELM-BERT: Topology-Aware Representations for Chemically Modified Peptides Seungeon Lee, Takuto Koyama, Itsuki Maeda, Shigeyuki Matsumoto, Yasushi Okuno. (2026). Journal of Chemical Information and Modeling (JCIM)
  2. Empowering federated learning for robust compound–protein interaction prediction across heterogeneous cross-pharma domains Takuto Koyama, Hiroaki Iwata, Ryosuke Kojima, Takao Otsuka, Aki Hasegawa, Seungeon Lee, Hiroshi Ueda, Toshiharu Morimoto, Ryoko Sasaki, Nao Torimoto, Sei Murakami, Manabu Tojo, Teruki Honma, Shigeyuki Matsumoto, Yasushi Okuno. (2026). Journal of Cheminformatics

PREPRINTS

  1. HELM-BERT: A Transformer for Medium-sized Peptide Property Prediction Seungeon Lee, Takuto Koyama, Itsuki Maeda, Shigeyuki Matsumoto, Yasushi Okuno. (2025). arXiv PREPRINT

PRESENTATIONS

  1. TideFrag-GNN: A Fragment-Graph Foundation Encoder for Medium-Sized Peptide Property Prediction Seungeon Lee, Takuto Koyama, Itsuki Maeda, Shigeyuki Matsumoto, Yasushi Okuno. (2026.10.29). CBI Society Annual Meeting 2026 (Oral, O09-06) ORAL
  2. Comparative Evaluation of Peptide Representations and Similarity Measures Itsuki Maeda, Seungeon Lee, Yasushi Okuno. (2026.10.27). CBI Society Annual Meeting 2026 (Poster, P02-24) POSTER
  3. Early-Run Confidence-Based Computational Budget Triage for Antibody-Antigen Complex Structure Prediction Kyoka Iyanaga, Seungeon Lee, Takuto Koyama, Tomoaki Shima, Itsuki Maeda, Hiroki Shirai, Shigeyuki Matsumoto, Yasushi Okuno. (2026.10.27). CBI Society Annual Meeting 2026 (Poster, P06-26) POSTER
  4. HELM-BERT: Topology-Aware Representations for Chemically Modified Peptides Seungeon Lee, Takuto Koyama, Itsuki Maeda, Shigeyuki Matsumoto, Yasushi Okuno. (2026.08.03). 第18回 CBI若手の会講演会 (Online, Student Talk 5) ORAL
  5. ゼロからわかるChatGPT — Practical AI Adoption for Healthcare Teams Seungeon Lee. (2026.03.09). Yokawa Hospital (吉川病院), Miki, Hyogo (Invited) INVITED
  6. HELM-BERT: A Transformer for Medium-sized Peptide Property Prediction Seungeon Lee, Takuto Koyama, Itsuki Maeda, Shigeyuki Matsumoto, Yasushi Okuno. (2025.10.29). CBI Society Annual Meeting 2025 (Oral, O03-02) ORAL

RECENT WORKS

2026.10.29 AWARD Excellent Presentation Award — CBI Society Annual Meeting 2026 2026.10.29 TALK TideFrag-GNN: A Fragment-Graph Foundation Encoder for Medium-Sized Peptide Property Prediction — CBI Society Annual Meeting 2026 (Oral, O09-06) ORAL 2026.10.27 TALK Comparative Evaluation of Peptide Representations and Similarity Measures — CBI Society Annual Meeting 2026 (Poster, P02-24) POSTER 2026.10.27 TALK Early-Run Confidence-Based Computational Budget Triage for Antibody-Antigen Complex Structure Prediction — CBI Society Annual Meeting 2026 (Poster, P06-26) POSTER 2026.08.03 AWARD Excellent Lecture Award (優秀講演賞) — 第18回 CBI若手の会講演会 (CBI Wakate-no-Kai) 2026.08.03 TALK HELM-BERT: Topology-Aware Representations for Chemically Modified Peptides — 第18回 CBI若手の会講演会 (Online, Student Talk 5) ORAL 2026.07.15 ARTICLE HELM-BERT: Topology-Aware Representations for Chemically Modified Peptides — Journal of Chemical Information and Modeling (JCIM) 2026.07.12 WRITING 低分子創薬AIにおける表現学習・相互作用理解・候補分子設計の進展 — 月刊バイオインダストリー(CMC出版)2026年7月号 特集「AI創薬の最前線」 2026.03.09 TALK ゼロからわかるChatGPT — Practical AI Adoption for Healthcare Teams — Yokawa Hospital (吉川病院), Miki, Hyogo (Invited) INVITED 2026.01.10 ARTICLE Empowering federated learning for robust compound–protein interaction prediction across heterogeneous cross-pharma domains — Journal of Cheminformatics 2025.12.29 PREPRINT HELM-BERT: A Transformer for Medium-sized Peptide Property Prediction — arXiv 2025.10.30 AWARD Excellent Presentation Award — CBI Society Annual Meeting 2025 2025.10.29 TALK HELM-BERT: A Transformer for Medium-sized Peptide Property Prediction — CBI Society Annual Meeting 2025 (Oral, O03-02) ORAL

AWARDS

WRITINGS

SKILL

Python

Research experience with Python programming
Deep learning implementation with PyTorch

Machine Learning

Transformer-based language models
Peptide property prediction & federated learning

Cheminformatics

HELM notation for peptide representation
Compound-protein interaction modeling

Korean

Native speaker (mother tongue)

English

TOEIC 880

Japanese

JLPT N1

CONTACT

Feel free to reach out via SNS or email.